Neuro Protective Effect And Attenuation Of Dementia

Neuro-protective effect and attenuation of dementia by diltiazem in ICV-STZ induced sporadic Alzheimer s disease rat model. Ramesh Alluri* Sivamallikarjuna Reddy A Supriya Reddy G Cognitive Science Research Initiative Lab, Dept. of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak Dist., Telangana, 502313. Correspondence: rameshcology@gmail.com Abstract: Sporadic Alzheimer’s disease is an age-related neurological and psychiatric disorder characterized by impaired energy metabolism. Oxidative stress and neuro-inflammation have been implicated in pathophysiology of sporadic type of dementia. The Intra-cerebroventricular (ICV) administration of streptozotocin induces behavioural and biochemical alterations resembling those in sporadic type of Alzheimer’s patients. The present study was designed to investigate the effects of chronic pre-treatment with non-competitive calcium channel inhibitor diltiazem on cognitive dysfunction and oxidative stress markers in intra-cerebroventricular (ICV) streptozotocin-treated albino rats. Chronic treatment with diltiazem low dose 20mg/kg and 40 mg/kg orally on a daily basis for a period of 21 days, beginning 1 h prior to intra-cerebroventricular streptozotocin injection, significantly improved streptozotocin-induced cognitive impairment. Besides, improving cognitive dysfunction, chronic administration of highly selective calcium channel blocker diltiazem, reduced elevated malondialdehyde,